Estimated Time
1.00 hour
Release Date
Mar 15, 2023
Expiration Date
Feb 28, 2024
Activity Description
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, which typically occurs in patients over the age of 60 years. While chemoimmunotherapy (R-CHOP) has been considered the first line treatment option, approximately 40% of patient with DLBCL will fail to respond and experience a relapse. Autologous hematopoietic stem cell transplantation (AHCT) has been used as treatment for patients who experience a relapse; however, many patients are ineligible for the procedure due to age, comorbidities, or resistance to second-line chemoimmunotherapy. Novel treatment options have thus been introduced to the treatment landscape of DLBCL, including chimeric antigen receptor T-cell therapy (CAR T) with trial results displaying sustained remissions for relapsed patients. Because the options for treatment of DLBCL have changed rapidly, it is important for treating physicians to be aware of the options that are available as well as assist them in overcoming barriers that may impact their treatment.
Join us for this educational a Med Table Talk™ LIVE on Bridging the Gap to Reach Treatment Goals in DLBCL as our experts have a candid conversation about the available treatment options for DLBCL, how cellular therapists and community physicians must communicate to ensure adequate care between referring and treating physicians, and how to recognize and address common treatment barriers.
This taped satellite symposium was derived from the 2023 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCTTM and CIBMTR® on February 18, 2023.
Speakers
Christopher R. Flowers, MD, MS, FASCO
Division Head ad Interim, Division of Cancer Medicine
Chair, Professor, Department of Lymphoma/Myeloma
John M O'Quimm Endowed Chair in Cancer Research
MD Anderson Cancer Center
Houston, TX
Christopher R. Flowers, MD, MS joined The University of Texas MD Anderson Cancer Center in August 2019 as Chair of the Department of Lymphoma/Myeloma and was appointed Division Head ad interim of Cancer Medicine in August 2020. Through the COVID-19 pandemic, Dr. Flowers’ leadership contributed to the institution’s recovery in patient volume while maintaining accelerated safety measures. Prior to MD Anderson, he was professor of Hematology and Oncology with a joint appointment in Biomedical Informatics at Emory University School of Medicine in Atlanta. During his tenure there, he served the Winship Cancer Institute as director of the Lymphoma Program for 13 years and as scientific director of Research Informatics for four years. An internationally recognized expert in lymphoma clinical care, epidemiology and outcomes research, Dr. Flowers is an innovator who has a passion for facilitating new drug development. He is an active clinician who conducts clinical research involving cancer outcomes, cancer informatics, and phase 1/2 trials, focusing on the clinical development of novel therapeutics for B-cell lymphomas. His broader research interests include patient-oriented research in lymphoma and computer microsimulation models and cost-effectiveness analyses aimed at developing strategies to individualize care for cancer patients and improve systems of care. His work has resulted in >300 peer-reviewed publications. He has received peer-reviewed funding from foundations and the NIH including leading multi-institutional team science grants such as the Lymphoma Epidemiology of Outcomes (LEO) Cohort Study. The largest prospective study of lymphoma patients in the US.
Dr. Flowers has served in many capacities for national professional societies and was elected to membership in the American Society of Clinical Investigation. In 2018, he was named a Fellow of the American Society of Clinical Oncology (ASCO), and served as chair of both the ASCO guidelines on management of febrile neutropenia and ASCO Health Disparities Committee. In the American Society of Hematology, Dr. Flowers has served as educational co-chair for the annual meeting, a longstanding faculty member and co-director of the Clinical Research Training Institute, and Chair of the Committee on Promoting Diversity. In each of these roles, he has committed to training and developing new leaders in hematology and oncology clinical research.
Sergio A. Giralt, MD, FACP
Melvin Berlin Family Chair in Myeloma Research
Professor in Medicine, Weill Cornell Medical College
Deputy Head, Division of Hematologic Malignancies
Attending Physician, Adult BMT Service
Memorial Sloan Kettering Cancer Center
New York, NY
Sergio Giralt, M.D. - Professor of Medicine, Deputy Division Head of Hematologic Malignancies at Memorial Sloan-Kettering Cancer Center. His clinical research focus is on stem cell transplantation for patients with blood disorders. Dr Giralt trained and worked at the University of Texas M.D. Anderson Cancer Center, where he was Deputy Chair of the Department of Stem Cell Transplantation and Cellular Therapies. In May 2010, he joined the faculty of Memorial Sloan-Kettering Cancer Center to lead the Adult Bone Marrow Transplant Service and served as Chief until February 2020.
Sanjay K. Juneja, MD
Chief of Oncology Line
Mary Bird Perkins Cancer Center
Baton Rouge, LA
Dr. Sanjay Juneja is a triple board certified Hematologist & Medical Oncologist serving as Chief of Oncology Service at Baton Rouge General Hospital, and a social & news media personality known as 'TheOncDoc' with over half a million followers. He is an active participant for the White House Healthcare Leaders in Social Media Roundtable and national speaker. Dr. Juneja is the host of an innovative podcast called 'Target: Cancer' with distinguished academicians and celebrities around the country, and been featured in several articles including The Washington Post and guested on dozens of acclaimed podcasts and regional news channels (PBS, CBS, NBC, NPR). He is a Business Report's 40 under 40 recipient from his hometown of Baton Rouge, where he partners with the LA Department of Health and Mayor's office to optimize healthcare access and outreach. Dr. Juneja currently practices in his beloved hometown of Baton Rouge Louisiana with his wife Dr. Lauren and their three wild boys.
Sanjay Sharma, MD
St. Jude Crosson Cancer Institute
Providence OC Cancer Institute
Fullerton, CA
Dr. Sanjay Sharma is a highly accomplished hematologist oncologist with 18 years of experience at St Jude Heritage Medical Group, Providence Health System, Fullerton, CA. He has held various leadership roles during his tenure, including serving as Director of the Crosson Cancer Institute and has peer-reviewed publications. He graduated from medical school at Virginia Commonwealth Univ, internal medicine residency at Washington University in St Louis and fellowship at Mt Sinai Hospital NYC where he was chief fellow. In addition to his work in the medical field, Dr. Sharma is founder of Ishash Inc, a medical education company, founder of Physician Real Estate Nation, and general principal in multifamily syndications. Dr. Sharma is known for his dedication to improving the lives of his patients and for his commitment to advancing medical education and research.
Rayne H. Rouce, MD, BS
Associate Professor
Department of Pediatrics
Texas Children’s Cancer Center for Cell and Gene Therapy
Baylor College of Medicine
Houston, TX
Rayne Rouce, MD, BS, is a Pediatric Hematologist and Oncologist at Texas Children's Cancer Center where she is a member of the Leukemia and Bone Marrow Transplant Programs.
She received her medical degree from the University of Texas Medical Branch (UTMB) in Galveston, TX, then completed fellowship at Texas Children's Hospital. Dr. Rouce has spent the past several years of her career pioneering immunotherapy research for patients with refractory leukemia and lymphoma. Specifically, she works as part of a research program (The Center for Cell and Gene Therapy at Baylor College of Medicine) focused on translating targeted T cell therapies from the bench to bedside and has been involved in every aspect of CAR T cell development for clinical use. She has significant clinical experience in taking care of patients who have received CAR T cells and is passionate about ensuring patients and families understand this exciting new therapy.
Accreditation and Disclosure Information
Target Audience
This activity is intended for hematologic oncology clinicians (physicians, physician associates, nurses, pharmacists) who provide care for individuals with aggressive B-cell lymphomas who may be candidates for cellular therapy.
Educational Objectives
After completing this activity, the participant should be better able to:
- Assess the efficacy and safety of current and emerging therapeutic options for the treatment of R/R DLBCL
- Evaluate the potential use of a bridging therapies in patients with R/R DLBCL if the therapy goal is CAR-T or stem cell treatment
- Plan strategies to overcome barriers in accessing care and involvement in clinical trials for patients with DLBCL
Program Agenda
- Welcome
- Evaluate the latest standard of care for treating patients with DLBCL across various therapy lines
- Analyze how eligibility criteria for CAR-T and ASCT inform treatment decision-making throughout the disease course
- Communicate available non-CAR T treatment regimens for patients who are ineligible for CAR T-cell therapy or ASCT
- Implement strategies to dissolve issues related to access to therapy and clinical trials
- Recap of key points
Accreditation, Support and Credit
Continuing Medical and Professional Education: 2023 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR are sponsored by the Medical College of Wisconsin.
ACCME Accreditation Statement
The Medical College of Wisconsin is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education to physicians.
AMA Credit Designation
The Medical College of Wisconsin designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
In support of improving patient care, this activity has been planned and implemented by Medical Learning Institute, Inc., and the Medical College of Wisconsin. Medical Learning Institute, Inc. is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Nursing Continuing Professional Development
Successful completion of this nursing continuing professional development activity will be awarded 1.0 contact hour and 0.75 contact hour in the area of pharmacology.
Continuing Pharmacy Education
Medical Learning Institute, Inc. designates this enduring continuing education activity for 1.0 contact hour (0.1 CEU) of the Accreditation Council for Pharmacy Education.
Universal Activity Number: JA0007322-0000-23-020-H01-P
Type of Activity: Knowledge
AAPA Credit Designation Statement
Medical Learning Institute, Inc. has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credit. Approval is valid until February 28, 2024. PAs should only claim credit commensurate with the extent of their participation.
Support Statement
This activity is supported by an educational grant from Kite, a Gilead Company.
Disclosure & Conflict of Interest Policy
Medical Learning Institute, Inc. and the Medical College of Wisconsin are committed to providing high quality continuing education to healthcare professionals, as individuals and teams, with a protected space to learn, teach, and engage in scientific discourse free from influence from ineligible companies that may have an incentive to insert commercial bias into education. To that end, MLI requires faculty, presenters, planners, staff, and other individuals who are in a position to control the content of this CE activity to disclose all financial relationships they have had in the past 24 months with ineligible companies as defined by the ACCME, as related to the content of this CE activity, regardless of the amount or their view of the relevance to the education. All identified COI will be thoroughly vetted and mitigated according to MLI policy. These disclosures will be provided to learners prior to the start of the CE activity.
Faculty Disclosures
Planner/Presenter
Christopher R. Flowers, MD, MS, FASCO
Division Head, ad Interim, Division of Cancer Medicine
Chair, Professor, Department of Lymphoma/Myeloma
John M O’Quinn Endowed Chair in Cancer Research
MD Anderson Cancer Center
Houston, TX
Christopher R. Flowers, MD, MS, FASCO has a financial interest/relationship or affiliation in the form of:
Advisory Board/Consultant: AbbVie, AstraZeneca, Bayer, BeiGene, Bio Ascend, Bristol Myers Squibb, Celgene, Denovo Biopharma, Foresight Diagnostics, Genentech/Roche, Genmab, Gilead, Karyopharm, N Power, Pharmacyclics/Janssen, Seagen, Spectrum
Speakers’ Bureau: AbbVie, AstraZeneca, Bayer, BeiGene, Bio Ascend, Bristol Myers Squibb, Celgene, Denovo Biopharma, Foresight Diagnostics, Genentech/Roche, Genmab, Gilead, Karyopharm, Pharmacyclics/Janssen, Seagen, Spectrum
Research Grant: 4D, AbbVie, Acerta, Adaptimmune, Allogene, Amgen, Bayer, Celgene, Cellectis, EMD Serono, Genentech/Roche, Gilead, Guardant, Iovance, Janssen Pharmaceutical, Kite, Morphosys, Nektar, Novartis, Pfizer, Pharmacyclics, Sanofi
Stock Ownership: Foresight Diagnostics, N Power
Planner/Presenter
Sergio A. Giralt, MD, FACP
Melvin Berlin Family Chair in Myeloma Research
Professor of Medicine, Weill Cornell Medical College
Deputy Head, Division of Hematologic Malignancies
Attending Physician, Adult BMT Service
Memorial Sloan Kettering Cancer Center
New York, NY
Sergio A. Giralt, MD, FACP, has a financial interest/relationship or affiliation in the form of:
Advisory Board/Consultant: Actinium Pharmaceuticals, Inc., Amgen Inc., Bristol Myers Squibb, Celgene Corp., Janssen Pharmaceuticals, Omeros Corporation, Pfizer Inc., Sanofi, Takeda Pharmaceutical Co.
Research Grant: Actinium Pharmaceuticals, Inc, Amgen Inc., Bristol Myers Squibb, Celgene Corp., GlaxoSmithKline, Jazz Pharmaceuticals, Inc., Janssen Pharmaceuticals, Omeros Corporation, Pfizer Inc., Sanofi
Planner/Presenter
Sanjay K. Juneja, MD
Hematologist & Medical Oncologist
Chief of Oncology
Baton Rouge General Hospital
Mary Bird Perkins Cancer Center
Baton Rouge, LA
Sanjay K. Juneja, MD, has a financial interest/relationship or affiliation in the form of:
Advisory Board/Consultant: Daiichi Sankyo, Guardant 360
Speakers’ Bureau: AstraZeneca Pharmaceuticals, Daiichi Sankyo, Guardant 360, Merck & Co., Inc., Tempus
Stock Ownership: Phenomune, xCures
Independent Contractor: xCures
Planner/Presenter
Sanjay Sharma, MD
St. Jude Crosson Cancer Institute
Providence OC Cancer Institute
Fullerton, CA
Sanjay Sharma, MD has a financial interest/relationship or affiliation in the form of:
Speakers’ Bureau: Amgen, AstraZeneca, Bristol Myers Squibb, Guardant, Merck, Regeneron
Presenter
Rayne H. Rouce, MD, BS
Associate Professor
Department of Pediatrics
Texas Children’s Cancer Center for Cell and Gene Therapy
Baylor College of Medicine
Houston, TX
Rayne H. Rouce, MD, BS, has a financial interest/relationship or affiliation in the form of:
Advisory Board/Consultant: Novartis Pharmaceuticals Corporation, Pfizer Inc.
Research Grant: Tessa Therapeutics
All of the relevant financial relationships of individuals for this activity have been mitigated.
Planning Committee and Content/Peer Reviewers
The planners and content/peer reviewers from Medical Learning Institute, Inc. and the Medical College of Wisconsin, the accredited providers, do not have any relevant financial relationship(s) to disclose with ineligible companies unless listed below.
Disclosure of Unlabeled Use
This educational activity may contain discussions of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this CE activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the CE activity are those of the presenters and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Disclaimer
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this CE activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this CE activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.
Method of Participation
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