Demystifying the Evolving Science and Potential Role of Incretins in T2D

Estimated Time
1.25 hours

Release Date
Dec 07, 2022

Expiration Date
Jan 02, 2024

Despite the growing list of safe and effective therapies for individuals with T2D, many patients struggle to achieve their glucose target and thus remain at risk for significant comorbidities. Novel unimolecular dual agonists may help address these unmet needs. What role might novel agents play, and how can endocrinologists engage with their patients to make better therapeutic choices?   During the session, experts will explain the incretin effect and the roles of GLP-1 and GIP, as well as the potential benefits of agonism of multiple receptors that affect energy homeostasis; they will also interpret the clinical implications of new and emerging data for the first-in-class dual GLP-1 and GIP agonist. Case studies will identify individuals with T2D who may benefit from earlier treatment intensification to improve overall health and delineate practical considerations to help individuals with T2D achieve optimal outcomes.

This taped satellite symposium was derived from the IDF World Diabetes Congress on December 6, 2022.


Accreditation and Disclosure Information

This CE activity is intended for endocrinologists, diabetologists, and endocrinology fellows who provide care for individuals with T2D.

After completing this CE activity, participants should be better able to:

  • Identify individuals with T2D who may benefit from earlier treatment intensification to achieve optimal glucose control and overall health in accordance with current guidelines
  • Integrate practical considerations, experience, and SDM techniques to help individuals with T2D achieve and maintain weight loss for optimal outcomes
  • Relate the pathophysiology of GLP-1 and GIP to the incretin effect and potential benefits of agonism of multiple receptors that affect energy homeostasis and the MOA of novel therapies
  • Interpret the clinical implications of the efficacy and safety data of novel dual agonists for T2D and their potential impact on the treatment paradigm


  • Welcome and Introductions
  • Addressing Unmet Needs in T2D: Comorbidities, Treatment Intensification, Shared Decision Making for Weight Management
  • Demystifying the Evolving Science Behind the Incretin Effect and the Roles of GLP-1 and GIP; Benefits of Agonism of Multiple Receptors that Affect Energy Homeostasis; Mechanism of Action of Unimolecular Dual Agonists
  • Clinical Implications of Tirzepatide Efficacy and Safety Data; Identifying Ideal Candidates for Tirzepatide
  • Ask Me Anything: Incretins Edition — Final Q&A with Faculty
  • Concluding Comments and Key Points


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In support of improving patient care, this activity has been planned and implemented by Medical Learning Institute, Inc., and Endocrine Society. Medical Learning Institute, Inc. is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Medical Learning Institute, Inc. designates this enduring material for a maximum of 1.25 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ECMEC® Credit
The European Union of Medical Specialists-European Accreditation Council for Continuing Medical Education (UEMS-EACCME®) has an agreement of mutual recognition of continuing medical education (CME) credit with the American Medical Association (AMA). European physicians interested in converting AMA PRA Category 1 Credit(s)TM into European CME credit (ECMEC®) should contact the UEMS (

This activity is supported by an educational grant by Lilly.

Medical Learning Institute, Inc. and Endocrine Society are committed to providing high quality continuing education to healthcare professionals, as individuals and teams, with a protected space to learn, teach, and engage in scientific discourse free from influence from ineligible companies that may have an incentive to insert commercial bias into education.  To that end, we require faculty, presenters, planners, staff, and other individuals who are in a position to control the content of this CE activity to disclose all financial relationships they have had in the past 24 months with ineligible companies as defined by the ACCME, as related to the content of this CE activity, regardless of the amount or their view of the relevance to the education. All identified COI will be thoroughly vetted and mitigated according to policy. These disclosures will be provided to learners prior to the start of the CE activity. 


Bernhard Ludvik, MD
Associate Professor of Medicine
Head, 1st Medical Department
Landstrasse Clinic
Vienna, Austria

Bernhard Ludvik, MD, has a financial interest/relationship or affiliation in the form of:
Research Grant: Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Madrigal Pharmaceuticals, Novo Nordisk, Sanofi
Advisory Board/Consultant: Amgen, Boehringer Ingelheim, Daiichi Sankyo, Eli Lilly, Merck Sharp & Dohme, Novartis, Novo Nordisk, Sanofi
Speakers’ Bureau: Amgen, Boehringer Ingelheim, Daiichi Sankyo, Eli Lilly, Merck Sharp & Dohme, Novartis, Novo Nordisk, Sanofi

Stefano Del Prato, MD
Professor of Endocrinology
Chief – Section of Diabetes and Metabolic Diseases
Dept of Clinical and Experimental Medicine
University of Pisa
Pisa, Italy

Stefano Del Prato, MD, has a financial interest/relationship or affiliation in the form of:
Research Grant: AstraZeneca, Boehringer Ingelheim

Advisory Board/Consultant: Abbott, Applied Therapeutics, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Hengrui, Merck Sharp & Dohme, Novo Nordisk, Sandoz, Sanofi, Vertex
Speakers’ Bureau: AstraZeneca, Boehringer Ingelheim, Eli Lilly, Merck & Co., Novartis, Novo Nordisk, Sanofi

Thomas Forst, MD
Johannes Gutenberg University Mainz
Chief Medical Officer, Chairman of the Executive Board
Clinical Research Services
Mannheim, Germany

Thomas Forst, MD, has a financial interest/relationship or affiliation in the form of:
Advisory Board/Consultant: AstraZeneca, Atrogi, Bayer, Cipla, Eli Lilly, EyeSense, Fortbildungskolleg, Novo Nordisk, Pfizer, Sanofi, reMYND, Roche

Speakers’ Bureau: Amarin, AstraZeneca, Boehringer Ingelheim, Berlin Chemie, Cipla, Daiichi Sankyo, Eli Lilly, Fortbildungskolleg, Merck Sharp & Dohme, Novartis, Novo Nordisk, Sanofi, Santis

All of the relevant financial relationships of individuals for this activity have been mitigated.

The planners and content/peer reviewers from Medical Learning Institute, Inc., the accredited provider, and Endocrine Society, our educational partner, do not have any relevant financial relationship(s) to disclose with ineligible companies unless listed below.

This educational activity may contain discussions of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this CE activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the CE activity are those of the presenters and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this CE activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this CE activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.

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