Delve into the cutting-edge world of Cardiovascular-Kidney-Metabolic (CKM) Syndrome management in this CKM Dialogues previously recorded LIVE. This dynamic, expert-led, evidence-driven CME activity sheds light on the latest strategies for tackling CKM syndrome—a complex condition at the intersection of heart failure, chronic kidney disease, and type 2 diabetes. While individual guidelines exist for each disease, comprehensive guidance on managing their overlap is limited. CKM Dialogues LIVE brings together a multidisciplinary team of experts to bridge this gap with real-world insights and discussions on emerging therapies.
In this 60-minute session, Therapeutic Strategies for Cardiovascular-Kidney-Metabolic Syndrome: Addressing the Interconnected Triad of Heart Failure, Chronic Kidney Disease, and Diabetes, you'll explore the metabolic mechanisms driving CKM syndrome and examine current and novel treatments. Learners will be empowered to rethink treatment approaches and tailor therapies for the best patient outcomes.
This activity is derived from an independent satellite symposium at the 22nd World Congress on Insulin Resistance, Diabetes & Cardiovascular Disease, originally held on December 12, 2024.
Speakers
Jay H. Shubrook, DO, FACOFP, FAAFP
Jay H. Shubrook, DO is a Board-Certified family physician and a Fellowship trained Diabetologist. He is a Professor at Touro University California where he also serves as the Director of Diabetes Services. His research focus is on the prevention and early intervention for type 2 diabetes. He clinical and professional focus is on better training the primary care workforce to be prepared to help people manage diabetes. He is the Associate Editor of Clinical Diabetes and is the Chair of the Board of the American College of Diabetology. He was honored to serve on the AGA steering and writing committee for the NASH: A call to action guidelines for evaluation and treatment of NASH.
Jennifer B. Green, MD
Professor of Medicine
Division of Endocrinology
Duke Clinical Research Institute
Duke University School of Medicine
Durham, NC, USA
Dr. Green is a Professor of Medicine in the Division of Endocrinology at Duke University, a faculty member of the Duke Clinical Research Institute (DCRI), and was Chief of the Endocrinology section at the Durham VA Medical Center from 2003-2017. Dr. Green’s clinical practice and research have focused upon strategies to treat diabetes mellitus and reduce the risk of CV and other disease-related complications. She is presently the Duke University site PI, Publications Committee Co-Chair, and Executive Committee Member for GRADE, a federally-funded, long-term comparative effectiveness study of glucose-lowering medications for T2D. Her coordinating center experience has included clinical and operational leadership roles, protocol design and development, and oversight of endpoint event adjudication committees for several large, international trials designed to determine the CV effects of newer glucose-lowering medications (TECOS, EXSCEL, and Harmony Outcomes). She is currently the PI of the US coordinating center at DCRI and US national representative for the global EMPA-Kidney trial, and will hold similar roles in the upcoming EASi-Kidney trial. Dr. Green also has held multiple roles with the American Diabetes Association (ADA), including serving for several years on the organization’s Professional Practice Committee, serving as a member of the ADA-EASD writing group which recently revised their joint consensus statement on the management of hyperglycemia in type 2 diabetes, and she is currently an Associate Editor of Diabetes Care.
Pam R. Taub, MD, FACC, FASPC
Professor of Medicine
Director of Preventive Cardiology
Founder and Director of Step Family Cardiac
Rehabilitation and Wellness Center
University of California, San Diego
La Jolla, CA, USA
Pam R. Taub, MD, FACC, FASPC is a board-certified cardiologist and internationally recognized expert in cardiometabolic disease.
She is director of Preventive Cardiology and the founding director of the Step Family Foundation Cardiac Rehabilitation and Wellness Center, Director of Preventive Cardiology and Professor of Medicine at UC San Diego. Dr. Taub was responsible for all aspects of creating the center, which provides a comprehensive cardiac rehabilitation program for patients with established heart disease.
Her clinical practice focuses on preventive cardiology, lipidology, as well as women's cardiovascular health. Her research focuses on assessing the impact of behavioral, technological, and pharmacological interventions on cardiometabolic disease. Dr. Taub's is a federally funded researcher with funding from: the National Institutes of Health, Department of Defense, Department of Homeland Security and American Heart Association. She is an experienced clinical trialist and serves on the executive committee for multiple international clinical trials focused on novel cardiovascular therapies.
Dr. Taub is widely published (with over 100 publications) and has authored high impact publications in top peer-reviewed journals including Cell Metabolism and the Journal of the American College of Cardiology that have made an impact on clinical practice.
Dr. Taub holds multiple leadership positions in professional societies, serving as a fellow and board member for the American Society of Preventive Cardiology. She is a fellow and member of the American College of Cardiology Prevention of CV Disease Section Leadership Council. She also serves the Vice-Chair of the American Heart Association Council Women in Cardiology Committee.
Matthew R. Weir, MD
Professor and Chief, Division of Nephrology
Department of Medicine
University of Maryland School of Medicine
Baltimore, MD, USA
Matthew R. Weir, M.D. is attending physician and Director of the Division of Nephrology in the Department of Medicine at the University of Maryland Hospital, Baltimore. He is also Professor of Medicine at the University of Maryland School of Medicine.
Dr. Weir’s primary research interests include the use of antihypertensive therapy for the treatment of diabetic nephropathy, hypertensive renal injury in African Americans, cardiovascular disease in patients with chronic kidney disease, and mineralocorticoid receptor antagonism to treat atherosclerosis. He has written more than 700 manuscripts and book chapters about these topics. He has edited 8 books on topics in nephrology, transplantation, and hypertension. He has presented at numerous international scientific association meetings, hospitals, and medical schools.
Dr. Weir currently reviews manuscripts for more than 40 major medical journals, including the Journal of the American Society of Nephrology, New England Journal of Medicine, and Kidney International. He is on the editorial board of 22 journals and is an Associate Editor of Clinical Nephrology and the American Journal of Nephrology. He has 5 active NIDDK supported grants (2 R01 and 3 U01). In addition, he is a member of numerous associations, including the American Society of Nephrology, the National Kidney Foundation, the American Heart Association, and the American Society of Transplantation.
Dr. Weir received his medical degree from the University of Virginia, Charlottesville. He completed his internship and residency programs in medicine at the Waterbury and Yale-New Haven Hospitals in Connecticut and completed his nephrology training at the Brigham and Women’s Hospital, Harvard Medical School, in Boston, Massachusetts. He then moved to then to the University of Maryland where he has been a full-time faculty member since 1983.
Accreditation and Disclosure Information
Target Audience
This activity is intended for primary care physicians and other members of the multidisciplinary, interprofessional healthcare team in the U.S who care for patients with cardiovascular-kidney-metabolic syndrome.
Educational Objectives
After completing this activity, the participant should be better able to:
- Describe the complex interplay between CKD, HF, and T2D in the context of cardiovascular-kidney-metabolic syndrome.
- Analyze the epidemiological trends and pathophysiological mechanisms underlying the interconnectedness of HF, CKD, and T2D, and their implications for patient prognosis and quality of life.
- Evaluate the current evidence base supporting emerging therapeutic strategies, including sodium-glucose cotransporter 2 (SGLT2) inhibitors and aldosterone synthase inhibitors (ASIs), for managing cardiovascular-kidney-metabolic syndrome, with a focus on their potential to mitigate morbidity and mortality.
- Formulate evidence-based treatment plans for patients with cardiovascular-kidney-metabolic syndrome that consider the complex interactions between HF, CKD, and T2D to enhance patient quality of life.
Agenda
- Introduction
- Exploring the Connections Between CKD, HF, T2D
- Unveiling Epidemiological Trends and Pathophysiological Links
- Emerging Therapeutic Strategies for CKM Syndrome
- Tailoring Treatment for CKM syndrome
- Q&A with Expert Faculty
Accreditation, Support and Credit
This activity is provided by MLI
In support of improving patient care, Medical Learning Institute Inc is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Physician Continuing Medical Education
Medical Learning Institute Inc (MLI) designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
MOC Statement
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Participation information will be shared through the ACCME's Program and Activity Reporting System (PARS).
EBAC Credit
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PA
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Successful completion of this nursing continuing professional development activity will be awarded 1.0 contact hour and 0.5 contact hour in the area of pharmacology.
Continuing Pharmacy Education
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UAN: JA0007322-0000-25-003-H01-P
Support Statement
This activity is supported by an independent medical educational grant from Boehringer Ingelheim Pharmaceuticals, Inc and Eli Lilly and Company.
Disclosure & Conflict of Interest Policy
Medical Learning Institute Inc is committed to providing high quality continuing education to healthcare professionals, as individuals and teams, with a protected space to learn, teach, and engage in scientific discourse free from influence from ineligible companies that may have an incentive to insert commercial bias into education. To that end, MLI requires faculty, presenters, planners, staff, and other individuals who are in a position to control the content of this CE activity to disclose all financial relationships they have had in the past 24 months with ineligible companies as defined by the ACCME, as related to the content of this CE activity, regardless of the amount or their view of the relevance to the education. All identified COI will be thoroughly vetted and mitigated according to MLI policy. These disclosures will be provided to learners prior to the start of the CE activity.
Faculty Disclosures
Chair/Planner/Presenter
Jay H. Shubrook, DO, FACOFP, FAAFP
Professor Primary Care Department
Diabetologist
Touro University California
College of Osteopathic Medicine
Vallejo, CA, USA
Jay H. Shubrook, DO, FACOFP, FAAFP, has a financial interest/relationship or affiliation in the form of:
Consultant/Advisor: Abbott, Bayer, Eli Lilly, Madrigal, Novo Nordisk
Other: Member of American Diabetes Association, American College of Diabetology (Chair of the Executive Board), American College of Osteopathic Family Physicians, American Academy of Family Physicians, American Osteopathic Association and the Global NASH Council.
The following relationships have ended within the last 24 months:
Consultant/Advisor: Nevro (ended 6/2023), Sanofi (ended)
Planner/Presenter
Jennifer B. Green, MD
Professor of Medicine Division of Endocrinology
Duke Clinical Research Institute
Duke University School of Medicine
Durham, NC, USA
Jennifer B. Green, MD, has a financial interest/relationship or affiliation in the form of:
Consultant/Advisor: Anji, AstraZeneca, Bayer, Boehringer Ingelheim, Corcept, Lilly, Mineralys, Novo Nordisk, Pfizer, Valo, Vertex
Research Funding: Bluedrop, Boehringer Ingelheim, Lilly, Merck, Roche
Other: Member of the American Diabetes Association, Endocrine Society, European Association for the Study of Diabetes. Associate editor for Diabetes Care.
Planner/Presenter
Pam R. Taub, MD, FACC, FASPC
Professor of Medicine
Director of Preventive Cardiology
Founder and Director of Step Family Cardiac Rehabilitation and Wellness Center
University of California, San Diego
La Jolla, CA, USA
Pam R. Taub, MD, FACC, FASPC, has a financial interest/relationship or affiliation in the form of:
Consultant/Advisor: Amgen, Bayer, Boehringer Ingelheim, Edwards, Esperion, Jazz, Lilly, Medtronic, Merck, Novartis, Novo Nordisk, Sanofi
Contracted Researcher: Amgen, Merck, Novartis
The following relationships have ended within the last 24 months:
Consultant/Advisor: Amarin (ended 4/2024)
Contracted Researcher: Argenx (ended 1/2024)
Planner/Presenter
Matthew R. Weir, MD
Professor and Chief, Division of Nephrology
Department of Medicine
University of Maryland School of Medicine
Baltimore, MD, USA
Matthew R. Weir, MD, has a financial interest/relationship or affiliation in the form of:
Consultant/Advisor: AstraZeneca, Bayer, Boehringer Ingelheim, CSL Vifor, Mineralys, Novo Nordisk
All of the relevant financial relationships of individuals for this activity have been mitigated.
Planning Committee and Content/Peer Reviewers
The planners and content/peer reviewers from Medical Learning Institute Inc, the accredited provider, do not have any relevant financial relationships to disclose with ineligible companies unless listed below.
Disclosure of Unlabeled Use
This educational activity may contain discussions of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this CE activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the CE activity are those of the presenters and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Disclaimer
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this CE activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this CE activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.
Method of Participation
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About This Activity
Medical Learning Institute Inc is responsible for the selection of this activity’s topics, the preparation of editorial content, and the distribution of this CE activity. Our activities may contain references to unapproved products or uses of these products in certain jurisdictions. The preparation of this activity is supported by educational grants subject to written agreements that clearly stipulate and enforce the editorial independence of Medical Learning Institute Inc.
The materials presented here are used with the permission of the authors and/or other sources. These materials do not necessarily reflect the views of Medical Learning Institute Inc or any of its partners, providers, and/or supporters.
Resources
- Slides
- View from an Expert Bonus Content: Cardiology
- View from an Expert Bonus Content: Endocrinology
- View from an Expert Bonus Content: Nephrology
- View from an Expert Bonus Content: Primary Care/Family Medicine
Practice Aids
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Transcript: CKM Dialogues Live
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Transcript: View from an Expert Cardiology
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Transcript: View from an Expert Endocrinology
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Transcript: View from an Expert Nephrology
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Transcript: View from an Expert Primary Care/Family Medicine